Pyrrolidine Derivatives, Preparation Method, Pharmaceutical composition, useful as zinc metalloprotease inhibitors such as hydrolase to treat Myocardial Ischemia.Congestive heart failure, arrhythmia, hypertension, Asthma, atherosclerosis, cerebral vasospasm, Takayasu's arteritis, glaucoma, septicaemia.

摘要

The present Invention relates to compounds of formula I wherein R1, R2,.M and x are as defined in the description and Claims and dimeric forms and / or pharmaceutically acceptable esters and / or salts thereof.The compounds are useful as inhibitors of metalloproteases, e.g.Zinc proteases, in particular zinc Hydrolases, and are effective in the treatment of diseases associated with vasoconstriction of increasing incidence.