Compounds derived from pirrolinona, a prodrug, a Salt or a stereoisomer, Pharmaceutical composition useful in the treatment of a condition that presents a low bone mass in a Mammal.Fragility, such as osteoporosis, Osteoporotic fracture, alveolar bone loss, idiopathic infantile, mandibular osteotomy.

摘要

Agonist Selective for the prostaglandin receptor EP4 formula I Pharmaceutical compositions containing such compounds and their use in the treatment of disorders that have aLow bone mass, particularly Fragile, osteoporosis, Osteoporotic fracture, Bone defect, bone loss idiopathic infantile, alveolar bone loss,Mandibular bone loss, Bone fracture, osteotomy, bone loss associated with periodontitis or encarnamiento technician in a Mammal.Comprising administering these compounds.