Library of substances, Process for their Preparation and the use of this library to research active substances substances

摘要

Library refers to substances obtained by reaction of aromatic aldehyde, heteroaromaticos aliphatic Proton acid, without position or formula R9 co h; R9 is aryl,Heteroaryl alkyl, in Organic Solvents (toluene); in the presence of a base, POTASSIUM CARBONATE, Boric anhydride; at a temperature of - 10 degrees C to 110u00b0C,With Secondary amines to give animal compounds that REACT with acid chloride (acetyl chloride) in Solvent (diethyl ether) imino and react to form Salts.Purify in an organic Solvent (dimethyl sulfoxide.Acetonitrile, Toluene) with Naphthol, pyrrole, indole; Isolate and purify the compounds resulting from indole and Naphthol or REACT in Solution (dimethyl sulfoxide,Dimethylformamide) with halogenated compounds in the presence of a base (Tertiary Potassium butyrate, triethylamine,POTASSIUM hydroxide at a temperature of 10 degrees Celsius to 190u00b0C purification by Filtration through a Resin Binder and by Filtration through tris - (2 - Aminoethyl) Amine linked to Polymer3 - (3 - mercaptofenil) propanamidometilpoliestireno, then isolated by Conventional Methods.Active substances may be useful for treating Pain, allergies, inflammatory reactions, Drug Abuse, alcohol, diarrhea, gastritis, ulcer, cardiovascular diseaseUrinary incontinence, depression, State of shock, migrana, narcolepsy, obesity, asthma