This invention provides tissue selective estrogens of formula (I) having structure (I) wherein: R1 and R2 are independently, hydrogen, alkyl chain of 1-6 carbon atoms, benzyl, acyl of 2-7 carbon atoms, benzoyl, (1) or (2); X is hydrogen, alkyl of 1-6 carbon atoms, CN, halogen, trifuoromethyl, or thioalkyl of 1-6 carbon atoms; n = 1-3; with the proviso that at least one of R1 or R2 is (1) or (2); or a pharmaceutically acceptable salt thereof.
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机译:本发明提供了具有结构(I)的式(I)的组织选择性雌激素,其中:R 1和R 2独立地为氢,1-6个碳原子的烷基链,苄基,2-7个碳原子的酰基,苯甲酰基,(1)或(2); X是氢,1-6个碳原子的烷基,CN,卤素,三氟甲基或1-6个碳原子的硫代烷基; n = 1-3;前提是R1或R2中的至少一个是(1)或(2);或其药学上可接受的盐。
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