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TRANSGENIC NON-HUMAN ANIMALS EXPRESSING A GDF-11 DOMINANT NEGATIVE POLYPEPTIDE, AND METHODS OF MAKING AND USING SAME
TRANSGENIC NON-HUMAN ANIMALS EXPRESSING A GDF-11 DOMINANT NEGATIVE POLYPEPTIDE, AND METHODS OF MAKING AND USING SAME
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机译:表达GDF-11显性负多肽的转基因非人类动物及其制造和使用方法
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摘要
A transgenic non-human animal of the species selected from the group consisting of avian, bovine, ovine and porcine having a transgene which results in disrupting the production of and/or activity of growth differentiation factor-11 (GDF-11) chromosomally integrated into the germ cells of the animal is disclosed. Also disclosed are methods for making such animals, and methods of treating animals, including humans, with antibodies or antisense directed to GDF-11. The animals so treated are characterized by increased muscle tissue and bone tissue.
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