Human Monoclonal Antibodies that specifically bind to tnfsf13b with high specificity towards htnfs13b polypeptides, Nucleic Acids, and the condifican recombinant vectors,Pharmaceutical composition containing useful to inhibit the activity of tnfsf13b in vitro and in vivo.

摘要

Human Monoclonal Antibodies that specifically bind to tnfsf13b polypeptides.These Antibodies have a High affinity toward htnfsf13b (For example kd = 10 - 8 m or less), a slow speed of separation for the Dissociation of tnfsf13b (e.g. PSEP = 10 - 3 S - 1Or less) and tnfsf13b neutralizing activity in vitro and in vivo.The Antibodies of the invention are useful for inhibiting the activity tnfsf13b in a Human subject suffering from a disorder in which the activity htnfsf13b is harmful.Also encompassed by the invention are Nucleic Acids encoding the Antibodies of the present Invention,The recombinant Vectors and Pharmaceutical composition containing them and their use in the preparation of a Medicament useful in the treatment of autoimmune diseases.