Bicyclic Pyrimidines and Bicyclic 3,4-Dihydropyrimidines as Inhibitors of Cellular Proliferation, Compositions Containing Them and Methods for Treating Cell Proliferative Disorders

摘要

1. Technical Result Increase in efficiency of treatment of cell proliferative disorders. 2. Essence A composition of the formula wherein values of R1, R2, R3, R8, R9, W, Z, G and X are defined in the specification; preferably Z is N or CH; G is N or CH; W is NH, S, SO, or SO2, R1 includes phenyl and substituted phenyl, R2 includes alkyl and cycloalkyl, R3 includes alkyl and hydrogen, R8 and R9 include hydrogen and alkyl; the mentioned compounds are potent inhibitors of cyclin-dependent kinases (cdks), growth factor-mediated kinases, and non-receptor kinases and are used for treating cell proliferative disorders, such as cancer and restenosis, as well as angiogenesis and atherosclerosis. The pharmaceutical composition as an active compound comprises the mentioned formulation in pharmaceutically acceptable amount. 3. Field of Application Medicine. Tables: 7