Pyrroloindoles, pyridoindoles and azepinoindoles useful as 5-HT2C agonists

摘要

A pyrroloindole, pyridoindole or azepinoindole derivative, or pharmaceutically acceptable salts thereof has the formula (I) wherein: n is 1, 2 or 3; R1 and R2 are independently hydrogen or alkyl; R3 is alkyl; R4 to R7 are independently hydrogen, halogen, hydroxy, alkyl, aryl, alkoxy, aryloxy, alkylthio, arylthio, alkylsulphoxyl, alkylsulphonyl, arylsulphoxyl, arylsulphonyl, amino, monoalkylamino, dialkylamino, nitro, cyano, carboxaldehyde, alkylcarbonyl, arylcarbonyl, aminocarbonyl, monoalkylaminocarbonyl, dialkylaminocarbonyl, alkoxycarbonylamino, aminocarbonyloxy, monoalkylaminocarbonyloxy, dialkylaminocarbonyloxy, monoalkylaminocarbonylamino or dialkylaminocarbonylamino, or R5 and R6 together form a carbocyclic or heterocyclic ring. The compounds are useful in treating central nervous system; damage to the central nervous system; cardiovascular disorders; gastrointestinal disorders; diabetes insipidus, and sleep apnea