ABSOLUTE CONFIGURATION DETERMINING AGENT OF OPTICALLY ACTIVE SUBSTANCE, ITS MANUFACTURING METHOD, AND ABSOLUTE CONFIGURATION DETERMINING METHOD OF THE SUBSTANCE

摘要

PPROBLEM TO BE SOLVED: To provide an absolute configuration determining agent of optically active substance which can simply determine the absolute configuration of the optically active substance, by using a trace amount of a sample, a method for manufacturing the agent, and a method for determining the absolute configuration of the optically active substance by using the agent. PSOLUTION: The absolute configuration determining agent of optically active substance, whose optical purity is at least 20%, is provided. The agent is composed of 1-alkoxybicyclo[3.3.0]-2-oxaoctane, as shown by general formula [1], 1-hydroxybicyclo[3.3.0]-2-oxaoctane, as shown by general formula [2] or bicyclo[3.3.0]-2-oxa-1-octene, as shown by general formula [3]. The absolute configuration determining method of optically active substance is provided. In the method, optically active substance is made to react with the compound expressed by one of the general formulas [1]-[3], and the absolute configuration of optically active substance is determined by measuring the obtained nuclear magnetic resonance spectrum of diastereomer. In addition, the method for manufacturing the absolute configuration determining agent, composed of the compound expressed with the general formulas [1]-[3], is provided. PCOPYRIGHT: (C)2004,JPO