3-Indoline derivatives useful for psychiatry and treatment of neurological disorders

摘要

The present invention relates to methods of treating psychiatric or neurologic disorders, in particular psychoses, by administration of a compound formula of (I) wherein R1 is acyl, thioacyl, trifluoromethylsulfonyl or R1 is a group R12SO2-, R12OCO- or R12SCO- wherein R12 is C1-6-alkyl, C2-6-alkenyl, C2-6-alkynyl, C3-8-cycloalkyl, C3-8-cycloalkyl-C1-6-alkyl or aryl, or R1 is a group R13R14NCO, R13R14NCS-, wherein R13 and R14 are independently hydrogen, C1-6-alkyl, C2-6-alkenyl, C2-6-alkynyl, C3-8-cycloalkyl, C3-8-cycloalkyl-C1-6-alkyl or aryl, or R13 and R14 together with the N-atom to which they are linked form a pyrrolidinyl, piperidinyl or perhydroazepin group; n is 1-6; X is C, CH or N, and the dotted line emanating from X indicates a bond when X is C and no bond when X is N or CH; R', R'' and R2 are independently selected from hydrogen and C1-6-alkyl; R3-R11 are independently selected from hydrogen, halogen, cyano, nitro, C1-6-alkyl, C2-6-alkenyl, C2-6-alkynyl, C3-8-cycloalkyl, C3-8-cycloalkyl-C1-6-alkyl, amino, C1-6-alkylamino, di-(C1-6-alkyl)amino, C1-6-alkylcarbonyl, aminocarbonyl, C1-6-alkylaminocarbonyl, di-(C1-6-alkyl)aminocarbonyl, C1-6-alkoxy, C1-6-alkylthio, hydroxy, trifluoromethyl, trifluoromethylsulfonyl and C1-6-alkylsulfonyl; or a pharmaceutically acceptable acid addition salt thereof.