;In another embodiment, the peptide mimetic has the following structure: chemistry chemdraw filechemistry mol file;In yet another embodiment, the peptide mimetic has the following structure: chemistry chemdraw filechemistry mol file"/>
Peptide analogs and mimetics suitable for in vivo use in the treatment of diseases associated with abnormal protein folding into amyloid, amyloid like deposits or beta sheet rich pathological precursor thereof
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Peptide analogs and mimetics suitable for in vivo use in the treatment of diseases associated with abnormal protein folding into amyloid, amyloid like deposits or beta sheet rich pathological precursor thereof
Peptide analogs and mimetics suitable for in vivo use in the treatment of diseases associated with abnormal protein folding into amyloid, amyloid like deposits or beta sheet rich pathological precursor thereof
The present invention is an inhibitory peptide capable of inhibiting pleated sheet formation in amyloid -peptide. The inhibitory peptide is a sheet breaker peptide analog designed by chemical modification of a sheet breaker peptide capable of inhibiting pleated sheet formation in amyloid -peptide. ;The present invention also includes an inhibitory peptide capable of inhibiting conformational changes in prion PrP protein associated with amyloidosis. The inhibitory peptide being a sheet breaker peptide analog designed by chemical modification of a sheet breaker peptide capable inhibiting the conformational changes in prior PrP protein associated with amyloidosis. ;In addition, the present invention includes a peptide mimetic with the following structure: chemistry chemdraw filechemistry mol file;In another embodiment, the peptide mimetic has the following structure: chemistry chemdraw filechemistry mol file;In yet another embodiment, the peptide mimetic has the following structure: chemistry chemdraw filechemistry mol file展开▼
机译：本发明是一种能够抑制淀粉样肽中的褶皱片形成的抑制肽。抑制肽是通过化学修饰能够抑制淀粉样肽中的褶皱片形成的片断裂肽设计的片断裂肽类似物。本发明还包括能够抑制与淀粉样变性有关的病毒PrP蛋白的构象变化的抑制肽。该抑制肽是通过化学修饰能够破坏先有的与淀粉样变性有关的PrP蛋白的构象变化的阻肽肽而设计的阻肽肽类似物。另外，本发明包括具有以下结构的肽模拟物： <图像文件=“ US20040121960A1-20040624-C00001.GIF” he =“ 126.97965” id =“ EMI-C00001” imgContent =“ undefined” imgFormat =“ GIF” wi =“ 215.54505“ /> 化学chemdraw文件 化学mol文件 ;在另一个实施方案中，所述肽模拟物具有以下结构： <图像文件=“ US20040121960A1-20040624-C00002.GIF” he =“ 224.1918” id =“ EMI-C00002” imgContent =“ undefined” imgFormat =“ GIF” wi =“ 213.8724“ /> 化学化学绘图文件 化学mol文件 ;在又一个实施方案中，肽模拟物具有以下结构： <图像文件=“ US20040121960A1-20040624-C00003.GIF” he =“ 85.70205” id =“ EMI-C00003” imgContent =“ undefined” imgFormat =“ GIF” wi =“ 214.58115“ /> 化学化学绘图文件 化学mol文件
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