Compound, pharmaceutical compositions, methods for treating anxiety, depression, a sleep disorder, attention deficit disorder, or alzheimer's dementia, to increase the potency of a therapeutic effect of a cns agent, to determine the presence or absence of gabaa receptor in a sample, and to alter the signal transduction activity of gabaa receptor, and, use of a compound

摘要

"COMPOUND, PHARMACEUTICAL COMPOSITION METHODS FOR TREATMENT OF ANXIETY, DEPRESSION, SLEEP DISTURBANCE, ATTENTION DIFFICIT DISTURBANCE, OR ALZHEIMER DEMENTIA, TO INCREASE POTENTIAL EFFECTS OF EFFECTS GABA ~ A ~ RECEIVER IN A SAMPLE, AND TO ALTER GABA ~ A ~ RECEIVER SIGNAL TRANSDUCTION ACTIVITY, AND USE OF A COMPOUND ". Compounds of formula (I) and their pharmaceutically acceptable salts are presented, wherein the variables R1, R2, A, R4, R5, R6, R6 , N and W are as defined herein. These compounds that bind to the benzodiazepine site of GABA-A-1 receptors are provided and therefore can be used to modulate ligand binding to GABA-A-1 receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of central nervous system (CNS) disorders in humans, domesticated pets and farm animals.