compound or a pharmaceutically acceptable salt thereof, pharmaceutical composition, methods for treating anxiety, depression, a sleep disorder, attention deficit disorder or alzheimer's dementia, to enhance a therapeutic effect of a cns agent, to improve memory in a patient, to alter gabaa receptor signal transduction activity, and to determine the presence or absence of gabaa receptor in a sample, packaged pharmaceutical preparation, and use of a compound or salt

摘要

"COMPOUND OR A SALT OF THIS PHARMACEUTICALLY ACCEPTABLE, PHARMACEUTICAL COMPOSITION, METHODS FOR ANXIETY TREATMENT, DEPRESSION, A SLEEP DISTURBANCE, ATTENTION DEFICIT DISTURBANCE OR A DIFFERENT HEALTH CELL DISEASE SHORT-TERM MEMORY IN A PATIENT TO CHANGE GABA ~ A ~ RECEIVER SIGNAL TRANSDUCTION ACTIVITY, AND TO DETERMINE GABA ~ A RECEIVER PRESENCE OR ABSENCE IN A SAMPLE, PHARMACEUTICAL PREPARATION, AND COMPONENT, USE, AND USE OR SALT ". The compounds of Formula I are provided, as are the methods for their preparation. The variables Z ~ 1 ~, Z ~ 2 ~, Z ~ 3 ~, R ~ 4 ~, R ~ 5 ~, R ~ 6 ~, R ~ 7 ~, R ~ 8 ~ and Ar in the above formula are defined herein. Such compounds may be used to modulate ligand binding to GABA-A-receptors in vivo or in vitro and are particularly useful in treating a variety of central nervous system (CNS) disorders in humans, domesticated pets and animals. from creation. The compounds provided herein may be administered alone or in combination with one or more other CNS agents to potentiate the effects of the other CNS agent (s). Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands to detect GABA-Aβ receptors (e.g., receptor localization studies).