Process for the preparation of a therapeutically useful 1- (4-hydroxyphenyl) -1-hydroxy-2- (substituted amino) alkane compound and an intermediate used in the process

摘要

2-(8-Azabicyclo[3.2.1]oct-8-yl)alkanols of the formula IMAGE (I) wherein Q is S or CH=CH; X is H, OH or another aromatic substituent; R is hydrogen, alkyl, alkenyl or alkynyl; Y and Y1 are taken together and are arylmethylene or aralkylmethylene (or a corresponding epoxy derivative) or Y and Y1 are taken separately and Y is hydrogen or OH, and Y1 is aryl, aralkyl, arylthio, or aryloxy; and structurally related 2-(piperidino)alkanols; and 2-(pyriolidino)alkanols pharmaceutical compositions thereof; methods of treating CNS disorders therewith; and intermediates useful in the preparation of said compounds.