COMBINED B-CELL AND T-CELL EPITOPES ON VLP FOR IMPROVED VACCINES

摘要

A composition is described to induce simultaneous humoral (B-cell) and cell-mediated (CTL) immune responses against single or multiple antigens of a pathogenic virus bacteria, or cancer cell. Multiple B-cell and T-cell epitopes are identified in the pathogen proteome by computational and experimental techniques, and genetically inserted into a virus-like particle (VLP). Different insertion sites for B-cell and T-cell epitopes can be chosen at N-terminus, C-terminus or within the sequence of the VLP protein for optimal presentation of the epitopes.