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GENETICALLY PROFILED CELL LINES (GPCL) AND METHODS OF UTILIZING SAME FOR GENETIC DISSECTION OF CELLULAR PHENOTYPES
GENETICALLY PROFILED CELL LINES (GPCL) AND METHODS OF UTILIZING SAME FOR GENETIC DISSECTION OF CELLULAR PHENOTYPES
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机译:遗传异型细胞系(GPCL)和利用相同方法进行细胞表型遗传分离的方法
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摘要
Genetically profiled cell cultures are provided along with a dataset representing the genetic profile of the cells. Also provided are methods and kits using same for the identification of the genetic basis of a trait, a disease or a state which can be directly or indirectly measured in a cell-based assay. In addition, the methods provided by the present invention can be used to: (i) identify novel drugs for the treatment and/or prevention of diseases (ii) determine population variation to drug responsiveness, efficacy, toxicity and adverse effects, and (iii) to optimize the drug lead process.
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