Methods for improved production of a viral agent, for the production of cell lines exhibiting permanent genetic modification for the production of eukaryotic cell lines permissive.To improve the yield of recombinant products, functional viral agent, line of the selected cell to exhibit permanent genetic modification.The lineage of eukaryotic cells permissive, and recombinant product functional

摘要

"Methods for improved production of a viral agent, for the production of cell lines exhibiting permanent genetic modification.For the production of eukaryotic cell lines permissive, to improve the yield of recombinant products, functional viral agent.Line of the selected cell to exhibit permanent genetic modification, eucarioticas permissive cell line, and recombinant product functional. Method for increasing the production yield of virus, viral proteins.And other biological materials related through improved control and stabilization of protein production via protein of stress and the resulting protein products.This invention is also directed to methods for selection or engineering of cell lineages in these stabilised products improved.More specifically, ways of realization of example of the present invention is directed to methods for improving the production of a viral agent.Production of cell lines showing permanent genetic modification, production of eukaryotic cell lines permissive, improving yield of recombinant product functional.And the products of these methods.