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Combination of allosteric inhibitor of matrix metalloproteinase-13 and celecoxib or valdecoxib
Combination of allosteric inhibitor of matrix metalloproteinase-13 and celecoxib or valdecoxib
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机译:基质金属蛋白酶-13的变构抑制剂与塞来昔布或伐地考昔的组合
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摘要
This invention provides a combination, comprising an allosteric inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, with celecoxib, or a pharmaceutically acceptable salt thereof, or valdecoxib, or a pharmaceutically acceptable salt thereof. This invention also provides a method of treating a disease that is responsive to inhibition of MMP-13 and cyclooxygenase-2, comprising administering to a patient suffering from such a disease the invention combination. This invention also provides a pharmaceutical composition, comprising the invention combination and a pharmaceutically acceptable carrier, diluent, or excipient. The invention combination may also be further combined with other pharmaceutical agents depending on the disease being treated.
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