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Methods of improving screening, diagnosis and staging of prostate cancer using serum testosterone
Methods of improving screening, diagnosis and staging of prostate cancer using serum testosterone
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机译:使用血清睾丸激素改善前列腺癌的筛查,诊断和分期的方法
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摘要
The present invention provides methods of screening for, detecting or diagnosing prostate cancer in a subject by determining the level of prostate specific antigen (PSA), complexed PSA (cPSA), free PSA, B-PSA, PRO-PSA or HK2 in a biological sample from the subject and correcting this level for free/bioavailable serum testosterone, total testosterone or sex hormone binding globulin. The present invention further relates to identifying a subject at risk for developing prostate cancer or for determining the effectiveness of anti-cancer therapy in a subject having prostate cancer, or for detecting cancer recurrence by determining the level of prostate specific antigen (PSA), complexed PSA (cPSA), free PSA, B-PSA, PRO-PSA or HK2 in a biological sample from the subject and correcting this level for free or bioavailable serum testosterone, total testosterone or a testosterone bound protein, including but not limited to sex hormone binding globulin.
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