humanized antibodies, method for inhibiting binding of interferon-i to receptor-1, for inhibiting an immune response, for treating an autoimmune disorder, for modifying serum crp levels, for serum neopterin levels and for modifying proliferation of b-cells, and chimeric antibody

摘要

"HUMANIZED ANTIBODIES, METHOD FOR INHIBITING INTERFERON-I CONNECTION-1 BINDING, FOR INHIBITION OF AN IMMUNE RESPONSE, TO TREAT AUTOIMMUN DISORDER, TO MODIFY SERP CRP LEVELS FOR NEOPTERINE MODIFYER LEOPHERIN B-CELL AND CHEMICAL ANTIBODY ". Humanized IFNAR-1-binding monoclonal antibodies, and related antibody-based compositions and molecules, are disclosed. Also disclosed are pharmaceutical compositions comprising humanized antibodies and therapeutic and diagnostic methods for using humanized antibodies.