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Hamster and murine cells incorporating anti-apoptosis gene of the BCL-2 family having improved cell survival properties and methods to generate such cells
Hamster and murine cells incorporating anti-apoptosis gene of the BCL-2 family having improved cell survival properties and methods to generate such cells
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机译:结合了具有改善的细胞存活特性的BCL-2家族抗凋亡基因的仓鼠和鼠细胞以及产生这种细胞的方法
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摘要
Described are hamster and murine myeloma host cells, modified by introducing nucleic acid sequences that encode for an anti-apoptosis gene, a selectable amplifiable marker and at least one gene of interest. Preferably the anti-apoptosis gene is from the Bcl-2 superfamily. Also described are, methods of generating host cells showing enhanced expression levels of an anti-apoptosis genes, and host cells comprising at least 5 copies of a heterologous anti-apoptosis gene.
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