Host cells having improved cell survival properties and methods to generate such cells

摘要

The present invention relates to genetically engineered mammalian host cells comprising enhanced levels of active anti-apoptotic genes and methods of making such host cells. More particularly, the present invention relates to methods for regulating the levels of anti-apoptotic genes in host cells and host cells that exhibit enhanced cell viability by delaying / inhibiting programmed cell death that occurs naturally in such host cells. . The invention also provides novel anti-apoptotic genes suitable for producing host cells exhibiting enhanced cell viability by delaying / inhibiting programmed cell death occurring naturally in the host cell.;Anti-apoptotic genes, programmed cell death, apoptosis, cell viability