A BIOMIMETIC PROCESS FOR COATING SUBSTRATES WITH A BIOMIMETIC SOLUTION CONTAINING A BIOACTIVE SUBSTANCE AND USE OF SAID PROCESS AND SUBSTRATES IN BONE-, CONNECTIVE TISSUE-, FAT TISSUE- AND MUSCLE TISSUE ENGINEERING

摘要

The invention relates to a biomimetic process for coating a substrate,particularly a medical device, with a biomimetic composition, which comprises:a) producing batchwise in a closed system an acidified biomimetic compositioncomprising a saline aqueous mixture containing calcium-, magnesium-, phosphate-, bicarbonate ions and a bioactive substance, b) contacting the substrate withsaid biomimetic composition and c) storing the biomimetic composition incontact with the substrate and allowing a gradual increase of the pH to occurand to cause precipitation of salts and co-precipitation of the bioactivesubstance on said substrate and to obtain a coated substrate.