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Protecting a patient from possible adverse effects of inhibition of the SHH- signaling pathway by suppressing testosterone
Protecting a patient from possible adverse effects of inhibition of the SHH- signaling pathway by suppressing testosterone
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机译:通过抑制睾丸激素保护患者免受SHH信号通路抑制的可能不利影响
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摘要
A method of protecting a patient from possible adverse effects of a treatment involving inhibition of the SHH-signalling pathway in the patient, the method comprising suppressing testosterone or its effect in the patient. A method of treating a proliferative disease such as cancer in a patient the method comprising inhibiting the SHH-signalling pathway and suppressing testosterone or its effect in the patient. Typically, the SHH-signalling pathway is inhibited using cyclopamine or a derivative thereof, and testosterone is suppressed using any one or more of a GnRH antagonist, a GnRH agonist, an androgen antagonist or a Sa-reductase inhibitor.
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