Process for the preparation of oxazoles by condensation of aromatic aldehydes with α-ketoximes to N-oxides and subsequent reaction with activated acid derivatives

摘要

The invention relates to a process for the preparation of oxazoles by condensation of aldehydes with alpha-ketoximes to N-oxides in the form of their salts or as free bases and subsequent reaction with activated acid derivatives to oxazoles in the form of their salts or as free bases, in particular the condensation between aromatic aldehydes and alpha-ketoximes, followed by reaction with inorganic thionyl halides or organic sulfonyl halides to give chloromethyloxazoles.