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A method for the production of oxazoles by condensation of aromatic aldehydes with α - ketoximes to n - oxides and subsequent reaction with activated acid derivatives

机译:一种通过芳族醛与α-酮肟肟缩合为正氧化物并随后与活化的酸衍生物反应生产恶唑的方法

摘要

The present invention relates to a process for the preparation of oxazoles by condensation of aldehydes with α - ketoximes to n - oxides in the form of their salts or as free bases and subsequent reaction with activated acid derivatives to oxazoles in the form of their salts or as free bases, in particular the condensation between aromatic aldehydes and α - ketoximes, followed by reaction with inorganic thionyl halogen identical or organic sulfonyl halides to chlorine methyl oxazoles.
机译:本发明涉及一种制备恶唑的方法,该方法是将醛与α-酮肟的盐或游离碱形式的缩合为正氧化物,然后与活化的酸衍生物以其盐或盐的形式与恶唑反应。作为游离碱,特别是芳族醛与α-酮肟之间的缩合,然后与相同的无机亚硫酰卤素或有机磺酰卤与氯甲基恶唑反应。

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