Methods of inhibiting hiv-1 vpr activity and hiv-1 infectivity using atr or rad17 inhibitors

摘要

Methods are disclosed for inhibiting the activity of a viral protein R (Vpr), inhibiting HIV replication, and treating or preventing an HIV infection through the use of an inhibitor of ATR or Rad17. Newly discovered ATR or Rad17 inhibitors are disclosed for use in accordance with the present invention, as are previously known compounds based upon their newly discovered property as inhibitors of ATR or Rad17.