Buccal, polar and non-polar spray or capsule containing drugs for treating pain

摘要

Disclosed is a propellant free buccal spray composition for transmucosal administration of a pharmacologically active compound comprising: an active compound in an amount of between 0.001 and 60 percent by weight of the total composition selected from the group consisting of anti-opioid agents, anti-migraine agents, pain control agents, anaesthetics, and mixtures thereof; and a polar solvent in an amount between 30 and 99 percent by weight of the total composition; wherein the anti-opioid agent is selected from the group consisting of nalmefene, cholecystokinin, nociceptin, neuropeptide FF, oxytocin, vasopressin, and mixtures thereof; the anti-migraine agent is selected from the group consisting of frovatriptan, zolmitriptan, rizatriptan, almotriptan, eletriptan, naratriptan, ergotamine, diethylergotamine, and mixtures thereof; and the pain control agent is selected from the group consisting of alfentanil, butorphanol, codeine, dezocine, fentanyl, hydrocodone, hydromorphone, levorphanol, meperidine, methadone, morphine, nalbuphine, oxycodone, oxymorphone, propoxyphene, pentazocine, sufentanil, tramadol, and mixtures thereof. Also disclosed are buccal aerosol sprays using polar and non-polar solvent which provide biologically active compounds for rapid absorption through the oral mucosa, resulting in fast onset of effect. The disclosed buccal polar compositions comprise formulation I: aqueous polar solvent, active compound, and optional flavoring agent; formulation II: aqueous polar solvent, active compound, optionally flavoring agent, and propellant; formulation III: non-polar solvent, active compound, and optional flavoring agent; and formulation IV: non-polar solvent, active compound, optional flavoring agent, and propellant.