METHOD FOR DETECTING THE ACTIVATABLE FREE FORM OF PSA AND THE USE THEREOF FOR DIAGNOSING BENIGN PATHOLOGIES OF THE PROSTATE AND ADENOCARCINOMA OF THE PROSTATE

摘要

The invention relates to an in vitro diagnostic method for diagnosing a benign pathology of the prostate or an adenocarcinoma of the prostate characterized by comprising a step for detecting the activatable free form of PSA in a biological sample from a patient suspected of having developed a benign pathology of the prostate or an adenocarcinoma of the prostate. This diagnostic method can be carried out by the following steps consisting of: i) bringing a binding partner capable of specifically binding to the activatable free PSA in contact with a biological sample from a patient suspected of having developed a benign pathology of the prostate or an adenocarcinoma of the prostate; ii) detecting the capture of the activatable free form of PSA by said binding partner; iii) calculating the ratio between the quantity of the activatable free form of PSA detected in step ii) and the quantity of a form of PSA other than the activatable free form present in a sample of the same type taken from the same subject, and; iv) determining if the patients are affected by an adenocarcinoma of the prostate or by a benign pathology of the prostate by comparing the value of the ratio determined in step iii) with a predetermined threshold value selected according to the type of ratio used and representative of the detection limit of each pathology.