CD8T CELL ACTIVATION-INHIBITING AGENT, AND THERAPEUTIC AGENT FOR RHEUMATISM AND DNA VACCINE FOR TREATING RHEUMATISM COMPRISING THE SAME

摘要

PPROBLEM TO BE SOLVED: To provide a CD8T cell activation-inhibiting agent, and a therapeutic agent for rheumatism and a DNA vaccine for treating rheumatism. PSOLUTION: The CD8T cell activation-inhibiting agent comprises a Jagged 1 gene or a Jagged 1 protein. The CD8T cell activation-inhibiting agent inhibits activation of a CD8T cell and accordingly makes prevention or treatment of rheumatism possible. Preferably, the gene above is particularly a structural gene in an extracellular region of the Jagged 1 protein. Preferably, a recombinant vector having the structural gene inserted therein is used as the DNA vaccine. PCOPYRIGHT: (C)2008,JPO&INPIT