NON-HUMAN MODEL ANIMAL WITH MENTAL RETARDATION, AND METHOD FOR SCREENING SUBSTANCE HAVING ACTIVITY FOR IMPROVING MENTAL RETARDATION SYMPTOMS

摘要

PROBLEM TO BE SOLVED: To provide a non-human model animal having mental retardation, and to provide a method for screening a substance having activity for improving mental retardation symptoms, using the model animal.;SOLUTION: The non-human model animal having mental retardation with PQBP-1 (polyglutamine tract binding protein-1) functions deleted is provided. The method for screening a substance, having the activity of ameliorating mental retardation symptoms using the model animal, is also provided.;COPYRIGHT: (C)2008,JPO&INPIT