PLATFORM FOR CHEMICAL AND BIOLOGICAL SENSING BY SURFACE-ENHANCED RAMAN SPECTROSCOPY

摘要

Methods of analysis, and compositions relating to such, to determine the presence or absence of an analyte in a sample utilizing a composite substrate which facilitates surface enhanced Raman spectroscopy through the use of ‘hot spots’ of the form ‘metal/analyte/metal’ are presented. Additionally, substrates which contain ‘hot spots’ of the form ‘metal/analyte/metal’ and substrates which facilitate the formation of ‘hot spots’ of the form ‘metal/analyte/metal’ are presented as well as methods for making these substrates.