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Three-dimensional culture containing human articular chondrocytes with induced terminal differentiation changes, and preparation process and uses of the same
Three-dimensional culture containing human articular chondrocytes with induced terminal differentiation changes, and preparation process and uses of the same
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机译:包含具有诱导的终末分化变化的人关节软骨细胞的三维培养物及其制备方法和用途
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摘要
Disclosed herein is a three-dimensional culture containing human articular chondrocytes with induced terminal differentiation changes, as well as a process for preparing the same. The three-dimensional culture, which was found to mimic the biological characteristics of articular chondrocytes that undergo terminal differentiation in vivo, can be used as a tool in the studies of the molecular and cellular mechanisms of osteoarthritis, and in the screening of candidate drugs for use in treatment of a disorder associated with articular chondrocytes.
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