methods to reprogram a source cell and a chondrocyte, to generate a cell, to prevent the differentiation of a chondrocyte cell culture, to treat osteoarthritis or another condition distinguished by the degeneration of cartilaginous tissue and to identify a useful agent to promote the conversion of a source cell type in a chondrocyte cell type, cell, cell population, uses of one or more compounds and a cell population, one or more of acid 4 - (5,6,7,8- tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl) carboxamido benzoic (am580), all trans retinoic acid, 9-cis retinoic acid, betaestradiol, calcitriol, ciglitazone, cartogenin, lithium chloride, melatonin, rhosin hydrochloride, leucovorin, vorinostat and forskolin, pharmaceutical composition, kit for use in a method, and processes for reprogramming a source cell, for generating a cell and for preventing the differentiation of a chondrocyte cell culture

摘要

the present invention relates to methods and compositions for reprogramming a source cell to produce a chondrocyte, the method comprising activating or enhancing protein expression of one or more transcription factors or variants thereof, in the source cell.