Substituted 10-aryl-11H-benzobfluorenes and 7-aryl-5, 6-dihydro-benzoaanthracenes for selective effects on estrogen receptors

摘要

This invention provides a compound, or its possible salt, having the formula,; wherein: R^e and ′R^e are OH, optionally independently etherified or esterified; Z is —CH₂CH₂— or —C(R⁴,R⁵)—, wherein R⁴ and R⁵ are independently H, (1C-2C)alkyl or form together a spiro(3C-5C)cycloalkyl; R¹ is H, halogen, CF₃, or (1C-4C)alkyl; R² and R³ are independently H, halogen, —CF₃, —OCF₃, (1C-8C)alkyl, hydroxy, (1C-8C)alkyloxy, aryloxy, aryl(1C-8C)alkyl, halo(1C-8C)alkyl, —O(CH₂)_mX, wherein X is halogen or phenyl and m=2-4; —O(CH₂)_mNR_aR_b, —S(CH₂)_mNR_aR_b or —(CH₂)_mNR_aR_b, wherein m=2-4 and wherein R_a, R_b are independently (1C-8C)alkyl, (2C-8C)alkenyl, (2C-8C)alkynyl, or aryl, which alkyl, alkenyl and aryl can optionally be substituted with halogen, —CF₃, —OCF₃, —CN, —NO₂, —OH, (1C-8C)alkoxy, aryloxy, carboxyl, (1C-8C)alkylthio, carboxylate, (1C-8C)alkyl, aryl, aryl(1C-8C)alkyl or halo(1C-8C)alkyl; or R_a and R_b form a 3-8 membered ring structure, optionally substituted with halogen, —CF₃, —OCF₃, —CN, —NO₂, hydroxy, hydroxy(1C-4C)alkyl, (1C-8C)alkoxy, aryloxy, (1C-8C)alkylthio, carboxyl, carboxylate, (1C-8C)alkyl, aryl, aryl(1C-8C)alkyl, halo(1C-8C)alkyl.