Substituted 10-aryl-11H-benzo b fluorene and 7-aryl-5,6-dihydro-benzo a anthracene for selective action on estrogen receptors

摘要

This invention provides a compound, or its possible salt, having the formula, wherein: RSUPe /SUPand 'RSUPe /SUPare OH, optionally independently etherified or esterified; Z is -CHSUB2/SUBCHSUB2/SUB- or -C(RSUP4/SUP,RSUP5/SUP)-, wherein RSUP4 /SUPand RSUP5 /SUPare independently H, (1C-2C)alkyl or form together a spiro(3C-5C)cycloalkyl; RSUP1 /SUPis H, halogen, CFSUB3/SUB, or (1C-4C)alkyl; RSUP2 /SUPand RSUP3 /SUPare independently H, halogen, -CFSUB3/SUB, -OCFSUB3/SUB, (1C-8C)alkyl, hydroxy, (1C-8C)alkyloxy, aryloxy, aryl(1C-8C)alkyl, halo(1C-8C)alkyl, -O(CHSUB2/SUB)SUBm/SUBX, wherein X is halogen or phenyl and m=2-4; -O(CHSUB2/SUB)SUBm/SUBNRSUBa/SUBRSUBb/SUB, -S(CHSUB2/SUB)SUBm/SUBNRSUBa/SUBRSUBb /SUBor -(CHSUB2/SUB)SUBm/SUBNRSUBa/SUBRSUBb/SUB, wherein m=2-4 and wherein RSUBa/SUB, RSUBb /SUBare independently (1C-8C)alkyl, (2C-8C)alkenyl, (2C-8C)alkynyl, or aryl, which alkyl, alkenyl and aryl can optionally be substituted with halogen, -CFSUB3/SUB, -OCFSUB3/SUB, -CN, -NOSUB2/SUB, -OH, (1C-8C)alkoxy, aryloxy, carboxyl, (1C-8C)alkylthio, carboxylate, (1C-8C)alkyl, aryl, aryl(1C-8C)alkyl or halo(1C-8C)alkyl; or RSUBa /SUBand RSUBb /SUBform a 3-8 membered ring structure, optionally substituted with halogen, -CFSUB3/SUB, -OCFSUB3/SUB, -CN, -NOSUB2/SUB, hydroxy, hydroxy(1C-4C)alkyl, (1C-8C)alkoxy, aryloxy, (1C-8C)alkylthio, carboxyl, carboxylate, (1C-8C)alkyl, aryl, aryl(1C-8C)alkyl, halo(1C-8C)alkyl.