AMINOCHINOLINE AND AMINOHINASOLINE KINASE MODULATORS

摘要

The present invention is directed to compounds of aminoquinoline and aminoquinazoline of the formula I where R, R, R, B, Z, Q, p, q and X are as defined herein, to the use of such compounds as protein tyrosine kinase modulators, in particular FLT3 and / or inhibitors TrkB, to the use of such compounds to reduce or inhibit FLT3 and / or TrkB kinase activity in a cell or subject, and to the use of such compounds to prevent or treat in a subject a disorder associated with cell proliferation and / or disorders associated with FLT3 and / or TrkB. The present invention is further directed to pharmaceutical compositions containing the compounds of the present invention, and to methods for treating conditions such as cancers and other disorders associated with cell proliferation.