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COPPER-MEDIATED FUNCTIONALIZATION OF ARYL C-H BONDS, AND COMPOUNDS RELATED THERETO
COPPER-MEDIATED FUNCTIONALIZATION OF ARYL C-H BONDS, AND COMPOUNDS RELATED THERETO
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机译:铜介导的芳基C-H键的功能及其相关化合物
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摘要
One aspect of the present invention relates to methods for direct functionalization of pyridyl-substituted aromatic compounds. In certain embodiments, 2-arylpyridine substrates react with anionic nucleophiies in the presence of copper(II) to furnish substituted arylpyridines. In other embodiments, the present invention allows for both mono- and di- functionalizations from manipulation of the reaction conditions. The transition metal- mediated carbon-heteroatom bond-forming methods are applicable to a variety of synthetic transformations of aryl C-H bonds.
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