ALBUMIN BINDING SITES FOR EVALUATING DRUG INTERACTIONS AND METHODS OF EVALUATING OR DESIGNING DRUGS BASED ON THEIR ALBUMIN BINDING PROPERTIES

摘要

A kind of method is provided for the evaluating drug compound of the bind properties based on them to human serum albumin, wherein the structural information in the specific albumin in binding region enters a Computer Database and assesses for being located at consistent particular contact binding residue of the invention. It obtains therefore being to assessing in albumin binding site and predict that drug interaction is useful by the information of Computer Database. Further it is provided that including the protein fragments of one or more albumin binding sites, it can be used for assessing and designing the method for drug.