AGENT FOR PROMOTING CELL PROLIFERATION USING ANTIMICROBIAL PEPTIDE AND METHOD FOR PROMOTING CELL PROLIFERATION USING SERUM-FREE MEDIUM CONTAINING THE SAME

摘要

In order to perform large-scale proliferation of synoviocytes and amnion-derived cells which are superior to stem cells in terms of differentiation into chondrocytes or neurons, it is intended to provide a peptide which has much fewer side effects or inhibitory effects on the living body and has a useful activity. The invention relates to an agent for promoting proliferation of amnion-derived cells or synoviocytes, comprising a peptide consisting of the following amino acid sequence: (1) the following amino acid sequence: Lys-Arg-Leu-Phe-Arg-Arg-Trp-Gln-Trp-Arg-Met-Lys-Lys-Tyr (SEQ ID NO: 1), or (2) an amino acid sequence in which one or several amino acids have been deleted, substituted or added in the amino acid sequence represented by SEQ ID NO: 1, and which has substantially the same activity of promoting cell proliferation as a peptide consisting of the amino acid sequence represented by SEQ ID NO: 1.