IMPROVED REGIMEN FOR TREATING CANCER WITH 5-FLUOROURACIL, 5,10-METHYLENETETRAHYDROFOLATE AND CAPECITABINE

摘要

The present invention provides a method of potentiating the therapeutic effect of 5-fluorouracil and 5,10 methylenetetrahydrofolate upon tumor load in a patient hosting 5-FU sensitive tumors. The first step of the method is cyclic administering to the patient a combination of 5-FU and 5,10 methylenetetrahydrofolate. The second of the method is administering capecitabine 1 day after the first step where the administration of capecitabine is in an amount that potentiates the therapeutic effect of 5-fluorouracil by reducing the tumor load in the patient to a greater amount than treatment with 5-FU and 5, 10-methylenetetrahydro folate without capecitabine.