A SUPERCRITICAL NANOPARTICLE PROCESS WITH VITAMIN K USING MOLECULAR ASSOCIATION THEORY

摘要

A method for preparing a nanostructure containing vitamin K is provided to solve a problem of remaining organic solvent by using a supercritical fluid extraction system and increase the skin permeation rate of the vitamin K by nano-sizing the vitamin K and control the medicinal effect delivering speed of a drug by containing a biodegradable polymer together with the drug. A method for preparing a nanostructure comprises the steps of: (a) dissolving vitamin K and a biodegradable polymer such as poly-isopropyl-butylmethacrylate-acrylic acid copolymer in an organic solvent such as ethanol to prepare a mixture solution; (b) spraying the mixture solution into a reactor containing a supercritical fluid such as CO2 to generate spherical vitamin K structure particles; (c) further introducing the supercritical fluid same as the step(b) into the reactor containing the spherical vitamin K structure particles to remove the organic solvent therefrom; and (d) recovering the organic solvent removed vitamin K structure particles.