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Male infertility-related gene protamine-2 mutation and diagnostic method for male infertility
Male infertility-related gene protamine-2 mutation and diagnostic method for male infertility
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机译:男性不育相关基因鱼精蛋白2突变及其诊断方法
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摘要
The present invention provides a group of mouse spermatogenesis genes, which is an assembly of 89 genes in total, wherein the respective genes transcribe mRNAs from which cDNAs having the respective base sequences of SEQ ID NOs:1 to 89 are synthesized; an Scot-t gene mutation and a protamine-2 gene mutation which are human homologues of genes belonging to the group of mouse genes and associated with human male infertility. The invention also provides a group of mouse spermatogenesis genes and various molecular biological materials relating thereto; various molecular biological materials relating to male infertility-associated gene mutations; and various test methods and diagnostic methods using the same.
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机译:本发明提供了一组小鼠精子发生基因,其总共是89个基因的集合,其中各个基因转录mRNA,由其合成具有SEQ ID NO:1至89的各个碱基序列的cDNA。 Scot-t基因突变和protamine-2基因突变,它们是属于小鼠基因组并与人类男性不育症相关的人类基因同源物。本发明还提供了一组小鼠精子发生基因及其相关的各种分子生物学材料。与男性不育相关基因突变有关的各种分子生物学材料;并使用相同的各种测试方法和诊断方法。
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