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Modulation of the integrin-linked kinase signaling pathway provides beneficial human cardiac hypertrophy and post myocardial infarction remodeling
Modulation of the integrin-linked kinase signaling pathway provides beneficial human cardiac hypertrophy and post myocardial infarction remodeling
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机译:整联蛋白相关激酶信号通路的调节提供了有益的人心脏肥大和心肌梗死后重塑
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摘要
Modulation of the integrin-linked kinase (ILK) signaling pathway is used to enhance the remodeling process relevant to a wide range of cardiac diseases. More specifically, a process for mediating a broadly adaptive form of human cardiac hypertrophy and a protective process for post myocardial infarction (MI), both comprising illiciting an overexpression of ILK, are described. Upregulation of ILK is also used in a process for affecting ILK mediated reduction of infarct size and beneficial increase in the left ventricular mass post MI.
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