4 - oxo - thiazole Derivatives, Pharmaceutical composition, method of preparing the same and their use in the manufacture of a Medicament for the treatment of diseases Modulated by Estrogen Related Receptor Alpha.

摘要

4-oxo-tiazol derivatives, pharmaceutical ingredients and methods of preparation and use of drugs used to treat diseases, including but not limited to peritonitis, water poison bacilli, arthritis (such as rheumatoid arthritis, infectious arthritis, ninez arthritis, psychoarthritis) Reactive arthritisBone related diseases (including those related to bone formation)Breast cancer (including breast cancer without estrogen therapy), cardiovascular disease, cartilage related diseases (such as cartilage damage / loss, cartilage degeneration) and cartilage formation related diseases,Condom, condom, chronic back injury, chronic bronchitis, chronic road inflammation, chronic obstructive pulmonary disease, diabetes, hypertension, gout, wig, lipid disorder, metabolic syndrome, multiple myeloma, obesity, skeletal inflammation, Incomplete osteoporosis, osteoporosis, osteoporosis, osteoporosis, Babbitt's disease, periodic disease, rheumatic multimite, Reiter syndrome, recurrent stress, hyperglycemia, hyperglycemia and insulin resistance. Item 1: a formula compound (1), wherein X is s or O, R1 is halogen,C1-4 alkyl optionally substituted, C1-4 alkoxy optionally substituted, or hydroxyl; R2 is selected from C1-3alkyl substituted by halo, cyano, halo, -C (O) NH2, and -C (O) O-C1-4alkyl, or alternatively R2 is attached together with R3 to form an aryl fused to the phenyl ring to which R2 and R3 are shown attached; R3 is H, or alternatively R3 is attached together with R2 to form an aryl fused to the phenyl ring to which R3 and R2 are shown attached; R4 is halo, cyano, C1-3 alkyl substituted by halo, -CsCH, -C (O) O-C1-4 alkyl, -C (O) NH2 or -S (O2) -C1-4 alkyl; and R5 and R6 are independently selected from H, optionally substituted C1-4 alkyl,Heteromorphic substitutes, isomerized substitutes or substitutes R5 and R6 are connected with N atom, and connected with N atom to form an isomerization, which contains alternative substitutes; or an optical isomer, dwarf, cholesterol, isomer, racemato, From a pharmaceutical point of view, acceptable salts or aquifers.