METHODS FOR HIGH EFFICIENCY SURVIVAL/PROLIFERATION OF HUMAN EMBYONIC STEM CELLS AND HUMAN EMBYRO SURVIVAL IN CULTURE

摘要

The present invention provides a role for neurotrophins in hES cell survival and important new insights into the molecular mechanisms controlling the growth of these cells. Although previous studies identified growth factors that affect self-renewal of hES cells, the novelty of the present invention is the identification of factors that act through specific receptors present on hES cells and activate the receptors at physiological concentrations to promote survival and proliferation.