PROCESS FOR OBTAINMENT OF ENANTIOMERS-OF N-(2,6-DIMETHYLPHENYL)-1-PROPYL-2-PIPERIDINOCARBOXAMIDE; PROCESS FOR OBTAINMENT OF NON-RACEMIC MIXTURES BETWEEN THE ENANTIOMERS OF N-(2,6-DIMETHYLPHENYL)-1-PROPYL-2-PIPERIDINOCARBOXAMIDE; NON RACEMIC MIXTURES OF ENANTIOMERS OF N-(2,6-DIMETHYLPHENYL)-1-PROPYL-2-PIPERIDINOCARBOXAMIDE;PHARMACEUTICALS COMPOSITIONS COMPRISING SAID NON-RACEMIC MIXTURES OF ENANTIOMERS OF N-(2,6-DIMETHYLPHENYL)-1-PROPYL-2-PIPERIDINOCARBOXAMIDE

摘要

The present invention describes a method of separation of the enantiomers of N-(2,6-dimethylphenyl)-1-propyl-2-piperidinocarboxamide. Another object of the present invention refers to the enantiomeric manipulation of the enantiomers of N-(2,6-dimethylphenyl)-1-propyl-2-piperidinocarboxamide, in order to achiever compounds and pharmaceutical compositions presenting diverse enantiomeric excesses of (S)-N-(2,6-dimethylphenyl)-1-propyl-2-piperidinocarboxamide, in order to quantify and determine the participation of (R)-N-(2,6-dimethylphenyl)-1-propyl-2-piperidinocarboxamide in the anesthetic and cardiotoxic effects. These compounds and compositions enantiomerically manipulated demonstrate to present a significant improvement in itsanesthetic properties, presenting a cardiotoxic profile equivalent to pure enantiomer, a (S)-N-(2,6-dimethylphenyl)-1-propyl-2-piperidinocarboxamide.