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A diagnostic aid and method for studying metabolic processes in the brain

机译:用于研究大脑中代谢过程的诊断辅助工具和方法

摘要

The invention relates to a diagnostic substance containing at least one complex composed of lipophilic anions and metal ions along with solvents, auxiliary agents, and/or carriers. The lipophilic anions are selected among the group comprising triethylenetetramine dihydrochloride (TETA), ethyl cysteinate dimer (ECD) methoxyisobutylisonitrile (MIBI), HMPAO (d,1,-hexamethylpropylene aminoxime) ethylenediamine-N,N,N'N'-tetraacetanilide (EDTAN), dimethyldithiocarbamate (DMC) and diethyldithiocarbamate (DDC), and glycin-N,N'-[1,2-ethanediylbis(oxy-2,1-phenylene)]bis[N-(carboxymethyl)-1,1'-bis[2-(octadecyloxy)ethyl]ester (DP-109) while the metal ions are selected among the group comprising thallium isotopes, lead isotopes, cobalt isotopes, and manganese isotopes. The inventive diagnostic substance is used for analyzing metabolism processes in the brain and/or the central nervous system.
机译:本发明涉及一种诊断物质,该诊断物质包含至少一种由亲脂性阴离子和金属离子以及溶剂,助剂和/或载体组成的络合物。亲脂性阴离子选自三亚乙基四胺二盐酸盐(TETA),半胱氨酸乙酯二聚体(ECD),甲氧基异丁基亚腈(MIBI),HMPAO(d,1,-六甲基丙烯氨基肟)乙二胺-N,N,N'N'-四乙酰苯胺(EDTAN) ),二甲基二硫代氨基甲酸酯(DMC)和二乙基二硫代氨基甲酸酯(DDC),以及甘氨酸-N,N'-[1,2-乙二基双(氧基-2,1-亚苯基)]双[N-(羧甲基)-1,1'-bis [2-(十八烷氧基)乙基]酯(DP-109),而金属离子选自comprising同位素,铅同位素,钴同位素和锰同位素。本发明的诊断物质用于分析脑和/或中枢神经系统的代谢过程。

著录项

  • 公开/公告号DE112006003775A5

    专利类型

  • 公开/公告日2008-11-27

    原文格式PDF

  • 申请/专利权人

    申请/专利号DE20061103775T

  • 发明设计人

    申请日2006-12-29

  • 分类号A61K49/00;

  • 国家 DE

  • 入库时间 2022-08-21 19:09:56

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