METHOD FOR EARLY DIAGNOSTICS OF CERVICAL INTRAEPITHELIAL NEOPLASIAS (CIN) BASED ON METABOLIC MARKERS STUDY

摘要

FIELD: medicine.;SUBSTANCE: invention is intended for early diagnostics of cervical intraepithelial neoplasias (CIN). Cervix pathology is identified. The level of predictor markers expression is determined by means of a Western blot analysis with chemiluminescence detection and real-time PCR. At expression levels of HIF1alpha 0.029, GLUT1 782.9±156.5, IGFBP-3 0.038±0.0076, HK2 36.4, VDAC1 70, CIN1 (LSIL) is diagnosed. At expression levels of HIF1alpha 0.03, GLUT1 1154.2±88.7, IGFBP-3 0.02±0.005, HK2 44.9, VDAC1 87, CIN2-3 (HSIL) is diagnosed.;EFFECT: effective diagnosis of cervical intraepithelial neoplasias at earlier stages.;5 dwg, 1 tbl, 3 ex