首页> 外国专利> PREVENTIVE AND/OR THERAPEUTIC COMPOSITION FOR DEGENERATIVE NEUROLOGIC DISORDER, CONTAINING LYCORIS CHEJUENSIS EXTRACT AND/OR COMPOUND ISOLATED THEREFROM

PREVENTIVE AND/OR THERAPEUTIC COMPOSITION FOR DEGENERATIVE NEUROLOGIC DISORDER, CONTAINING LYCORIS CHEJUENSIS EXTRACT AND/OR COMPOUND ISOLATED THEREFROM

机译：变性神经病的预防性和/或治疗性药物组合物，包含莱考氏天青提取物和/或分离的复方制剂

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摘要

PPROBLEM TO BE SOLVED: To develop a therapeutic agent having excellent effects on treating regressive neurologic disorders without causing side-effects, and enabling even causal treatment of the disorders. PSOLUTION: The composition and a health functional food for preventing, ameliorating and/or treating regressive neurologic disorders, contain a Cheju Island cluster amaryllis (Lycoris chejuensis) extract and/or dihydrolycoricidine, 2-methoxypancracine, and lycoricidine and/or lycoricidinol, being isolated from the extract, as active components. The methods of preparing the composition and health functional food, are also provided. PCOPYRIGHT: (C)2010,JPO&INPIT

机译：

要解决的问题：开发一种对退行性神经系统疾病具有极佳疗效而又不引起副作用，甚至能够对这些疾病进行因果治疗的治疗剂。

解决方案：用于预防，改善和/或治疗神经退行性疾病的组合物和健康功能食品，包含Cheju Island簇孤挺花（Lycoris chejuensis）提取物和/或二氢可可可啶，2-甲氧基泛cra碱和lycoricidine和/或lycoricidinol。从提取物中分离出来的活性成分。还提供了制备组合物和健康功能食品的方法。

版权：（C）2010，日本特许厅＆INPIT 展开▼

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公开/公告号JP2010202635A

专利类型
公开/公告日2010-09-16

原文格式PDF
申请/专利权人 KOREA ADVANCED INST OF SCI TECHNOL;
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申请/专利号JP20090244257
发明设计人 YANG HYUN-OK;KWON HAK-CHEOL;PARK JIN-SOO;CHUNG SUNG-KWON;KIN MEISHU;
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申请日2009-10-23
分类号A61K36/18;A61K36;A61K31/4355;A61K31/439;A61P21/02;A61P25/14;A61P25/16;A61P25/28;A23L1/30;C07D491/056;C07D491/18;
国家 JP
入库时间 2022-08-21 19:06:01

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V Garcia-Martinez, C Lopez Sanchez, W Hamed, 2016

10. Report of the Panel on Inflammatory, Demyelinating, and Degenerative Diseases to the National Advisory Neurological and Communicative Disorders and Stroke Council. Volume 7 [R] . 1979

1. Preventive and Therapeutic Potential of Vitamin C in Mental Disorders [J] . 韩倩倩 ,谌甜甜 ,王芳 . 华中科技大学学报：医学英德文版 . 2018,第1期

2. Regulatory role of long non coding RNAs (lncRNAs) in neurological disorders:From novel biomarkers to promising therapeutic strategies [J] . Nirjhar Bhattacharyya ,Vedansh Pandey ,Malini Bhattacharyya . 亚洲药物制剂科学(英文) . 2021,第5期

3. 保健食品复方沙棘清咽制剂提取物的质量标准研究 [C] . Zhao Cai-yun ,赵彩云 ,You Jia-li . 中华中医药学会第八次中药分析学术交流会 . 2015

4. 中药提取物复方制剂抗新城疫病毒的药效及质量控制 [A] . 马文才 . 2017